Treclin

Presciption Medicine
  • Treclin: Prescription topical acne treatment that combines an antibiotic and a retinoid to reduce inflammation and prevent blocked pores.
  • Active ingredient: Clindamycin and Tretinoin
  • Used for: Acne vulgaris
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Product Information

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Medically Verified
Dr. Cosmin Alexandru | Expert Transtoyou

Dr. Cosmin Alexandru

General Medicine Doctor | CUIM: 2791492305
Reviewed on: 7 March, 2026 View Profile

Dr. Cosmin Alexandru has 20+ years in emergency and family medicine, now serving at County Clinic Hospital Sibiu.

What is Treclin?

Treclin is a prescription topical acne treatment gel used to treat acne vulgaris, a common skin condition that causes pimples, blackheads and inflamed spots.

Treclin contains two active ingredients:

  • Clindamycin, an antibiotic that reduces acne-causing bacteria on the skin
  • Tretinoin, a retinoid (vitamin A derivative) that helps prevent blocked pores and promotes skin renewal

Acne develops when hair follicles in the skin become blocked by oil (sebum) and dead skin cells. This can lead to inflammation and bacterial growth.

Treclin works by addressing several of the main causes of acne at the same time. It reduces bacteria, clears clogged pores and helps the skin renew itself more effectively.

What is it used for?

Treclin is used to treat acne vulgaris, particularly when acne involves both blocked pores and inflamed spots.

It can help improve:

  • Pimples and inflamed spots
  • Blackheads and whiteheads
  • Blocked pores
  • Redness and inflammation

Treclin is commonly prescribed when acne affects the face and when topical treatment is appropriate.

Because Treclin combines an antibiotic with a retinoid, it targets multiple factors involved in acne development.

How does the product work?

Treclin contains two active ingredients that work together to treat acne.

Clindamycin

Clindamycin is an antibiotic that reduces the growth of Cutibacterium acnes, the bacteria involved in acne inflammation. By lowering bacterial levels on the skin, clindamycin helps reduce redness, swelling and infected pimples.

Tretinoin

Tretinoin is a retinoid that increases the turnover of skin cells. This helps prevent dead skin cells from blocking hair follicles.

Tretinoin works by:

  • Promoting skin cell renewal
  • Preventing clogged pores
  • Reducing blackheads and whiteheads
  • Improving overall skin texture

Together, these ingredients reduce inflammation and help keep pores clear, which can gradually improve acne.

Who should not use the product?

You should not use Treclin if:

  • You are allergic to clindamycin, tretinoin, lincomycin or any ingredients in the gel
  • You have inflammatory bowel disease such as ulcerative colitis or Crohn’s disease related to antibiotic use
  • You have a history of antibiotic-associated colitis
  • You have severe eczema or severely inflamed skin in the treatment area

Treclin should be used with caution if you:

  • Have very sensitive skin
  • Are using other strong topical acne treatments
  • Have severe sun sensitivity

Always follow your doctor’s advice and inform them about other skin treatments you are using.

Pregnancy and breastfeeding

Treclin should not be used during pregnancy, because tretinoin is a retinoid and may pose risks to an unborn baby.

If you are pregnant, planning pregnancy or think you may be pregnant, do not use Treclin.

If you are breastfeeding, speak to your doctor before using Treclin. Avoid applying the gel to areas where the infant could come into contact with the treated skin.

How to use and dosage

Always use Treclin exactly as prescribed.

The usual recommendation is:

  • Apply a thin layer once daily in the evening

How to apply:

  1. Wash your face with a mild cleanser and gently pat dry.
  2. Wait about 20 to 30 minutes before applying the gel.
  3. Apply a small amount of Treclin to the affected areas.
  4. Avoid the eyes, mouth and broken skin.

Using more gel than recommended will not improve results and may increase irritation.

It may take several weeks to see visible improvement in acne. Continue treatment as prescribed unless advised otherwise by your doctor.

Possible side effects

Like all medicines, Treclin may cause side effects, although not everyone experiences them.

Common side effects include:

  • Skin irritation
  • Dry skin
  • Redness
  • Peeling or flaking
  • Burning or stinging sensation

These effects are usually mild and often improve as your skin adjusts to treatment.

Less common side effects may include:

  • Increased sensitivity to sunlight
  • Severe skin irritation
  • Diarrhoea or abdominal pain (rarely due to antibiotic absorption)

If severe skin irritation or persistent gastrointestinal symptoms occur, stop using the gel and seek medical advice.

Important safety information

Before starting Treclin, tell your doctor if you:

  • Have sensitive skin
  • Have a history of inflammatory bowel disease
  • Are using other acne medications
  • Are using exfoliating or irritating skincare products

Treclin can increase your skin’s sensitivity to sunlight. During treatment:

  • Avoid excessive sun exposure
  • Use sunscreen daily
  • Avoid tanning beds

Do not apply Treclin to damaged, sunburned or irritated skin.

When to seek medical help

Seek medical attention if you experience:

  • Severe skin irritation or allergic reaction
  • Persistent diarrhoea or abdominal cramps
  • Severe redness or swelling of the skin
  • Signs of infection

Contact your doctor if:

  • Your acne worsens significantly
  • Skin irritation becomes severe
  • You do not see improvement after several weeks

If you are unsure whether your symptoms are related to your acne treatment, you can book a secure video consultation with a licensed doctor via Transtoyou for personalised advice. If symptoms are severe or sudden, seek urgent medical care immediately.

General Information

What is [Product name] used for?

Treclin is used to treat acne vulgaris, a skin condition that causes pimples, blackheads and inflamed spots. Treclin works by reducing acne-causing bacteria and preventing clogged pores.

How does [Product name] work in the body?

Treclin works by combining two active ingredients that target different causes of acne. Clindamycin reduces the bacteria involved in acne inflammation, while tretinoin increases skin cell turnover and helps prevent blocked pores.

How long does it take to feel the effects of [Product name]?

Treclin may start improving acne after several weeks of treatment. Most people see clearer skin after about 6 to 8 weeks of consistent use.

Does [Product name] contain an antibiotic?

Treclin contains clindamycin, which is a topical antibiotic. Clindamycin helps reduce the growth of Cutibacterium acnes bacteria that contribute to acne inflammation.

Can [Product name] be used for blackheads and whiteheads?

Treclin can help reduce blackheads and whiteheads because tretinoin prevents clogged pores and promotes normal skin cell turnover.

Safety & Side Effects

Can [Product name] make acne worse at first?

Treclin can sometimes cause an initial worsening of acne known as “purging.” This happens because tretinoin increases skin cell turnover and brings blocked pores to the surface.

Can [Product name] cause skin irritation?

Treclin commonly causes mild skin irritation such as dryness, redness, peeling or burning sensations. These effects are usually temporary and improve as the skin adapts to treatment.

Can [Product name] make your skin more sensitive to the sun?

Treclin can increase sensitivity to sunlight because it contains tretinoin. Daily sunscreen and avoiding excessive sun exposure are recommended during treatment.

Can [Product name] cause antibiotic resistance?

Treclin contains clindamycin, and long-term antibiotic use may contribute to bacterial resistance. For this reason, Treclin is typically used as part of a structured acne treatment plan.

Is [Product name] safe for long-term use?

Treclin may be used for several months if recommended by a doctor. Long-term treatment should be reviewed regularly to ensure the medication remains effective and appropriate.

Can I use this if I am pregnant or breastfeeding?

Treclin should not be used during pregnancy because it contains tretinoin, a retinoid that may harm an unborn baby.
Treclin may sometimes be used during breastfeeding if recommended by a doctor, but it should not be applied to areas where the infant could come into contact with treated skin.

Usage & Administration

How often should [Product name] be applied?

Treclin is usually applied once daily in the evening as a thin layer on the affected skin. Using more than recommended will not improve results and may increase irritation.

Can I use [Product name] together with moisturisers?

Treclin can be used with a gentle moisturiser to reduce dryness and irritation. Many dermatologists recommend applying moisturiser after Treclin has fully absorbed into the skin.

Can [Product name] be used with other acne treatments?

Treclin may sometimes be combined with other acne treatments such as benzoyl peroxide or oral medications, but this should only be done under medical advice to avoid excessive skin irritation.

What should I do if I miss a dose of [Product name]?

If you forget to apply Treclin, apply it the next evening as usual. Do not apply extra gel to make up for the missed dose.

Ordering & Delivery

How can I order [Product name] online?

To get [Product name], fill out a medical form or book a video consult with a doctor via Transtoyou. After approval, your prescription is sent to the pharmacy for fast delivery.

Do I need a prescription for [Product name]?

[Product name] requires a valid prescription, which is issued after the doctor reviewed your answered in the medical questionnaire or via a video consultation with the doctor.

How fast is [Product name] delivered?

After approval by a doctor from Transtoyou, the prescription of [Product name] is forwarded to an affiliated pharmacy and typically shipped within 1–2 working days.

Can I return [Product name] if I change my mind?

For safety and legal reasons prescription medication (RX) and in this case [Product name] is non-returnable once shipped.

What Treclin is and what it is used for?

Treclin is a topical acne treatment that contains two active substances: clindamycin and tretinoin.

Clindamycin is an antibiotic that reduces the growth of acne-causing bacteria and helps decrease inflammation in the skin. Tretinoin is a retinoid that helps regulate skin cell turnover and prevents blocked pores.

Treclin is used for:

  • Treatment of acne vulgaris in patients aged 12 years and older
  • Acne with both inflammatory lesions such as papules and pustules and non-inflammatory lesions such as blackheads and whiteheads

By combining antibacterial and comedolytic effects, Treclin helps reduce acne lesions and improve the appearance of the skin.

What you need to know before taking Treclin?

Do not use Treclin if you:

  • Are allergic to clindamycin, tretinoin, lincomycin or any of the ingredients
  • Have a history of inflammatory bowel disease such as ulcerative colitis or regional enteritis
  • Have previously experienced antibiotic-associated colitis
  • Have a history of skin cancer or a family history of skin cancer
  • Have acute eczema, rosacea or perioral dermatitis
  • Have severe forms of acne such as acne conglobata or acne fulminans

Treclin should not be used during pregnancy or by women who may become pregnant unless effective contraception is used.

Avoid contact with:

  • Eyes
  • Mouth
  • Lips
  • Mucous membranes
  • Broken or irritated skin

Treclin may increase sensitivity to sunlight. During treatment:

  • Limit exposure to sunlight
  • Use sunscreen with SPF 30 or higher
  • Avoid sunbeds or UV lamps

Certain skin products may increase irritation when used together with Treclin, including:

  • Peeling agents such as salicylic acid or benzoyl peroxide
  • Abrasive soaps or cleansers
  • Products with strong alcohol content

If severe diarrhoea or abdominal cramps occur, stop treatment and seek medical advice, as this may indicate antibiotic-associated colitis.

Treclin is not recommended for children under 12 years of age.

How to take Treclin?

Always use Treclin exactly as prescribed.

The usual dose is:

  • Apply once daily in the evening before bedtime

Before applying the gel:

  • Wash your face with a mild soap
  • Pat the skin dry

Apply a pea-sized amount of gel to the fingertip and dab it onto the chin, cheeks, nose and forehead, then gently spread a thin layer over the entire face.

Treclin is for external use only.

Avoid applying to:

  • Eyes or eyelids
  • Lips
  • Inside the nose
  • Broken or irritated skin

Wash your hands after applying the gel.

Treatment usually lasts up to 12 weeks, although improvement may take several weeks to become visible.

If you forget to apply Treclin:

  • Wait until the next scheduled application
  • Do not apply a double amount to make up for a missed dose

Using more than recommended may cause redness, peeling or irritation.

Possible side effects of Treclin

Like all medicines, Treclin can cause side effects, although not everyone experiences them.

Common side effects:

  • Dry skin
  • Redness
  • Skin peeling
  • Burning or stinging sensation
  • Skin irritation

Uncommon side effects:

  • Acne flare
  • Seborrhoea
  • Photosensitivity, increased sensitivity to sunlight
  • Skin itching
  • Rash
  • Sunburn

Rare side effects:

  • Hypersensitivity reactions
  • Headache
  • Eye irritation
  • Gastroenteritis
  • Nausea
  • Skin discoloration
  • Dermatitis
  • Skin swelling or pain at the application site

Stop using Treclin and seek medical advice if you experience:

  • Severe skin irritation
  • Signs of an allergic reaction
  • Persistent diarrhoea or abdominal cramps
How to store Treclin
  • Keep out of the sight and reach of children
  • Store below 25°C
  • Do not freeze
  • Keep the tube tightly closed
  • Use within 3 months after first opening
  • Do not use after the expiry date stated on the packaging

This leaflet summary does not replace the official patient information leaflet supplied with the medicine. Always read the full leaflet carefully before use and consult a doctor or pharmacist if you have any questions.

Product Documentation

This leaflet is provided for information purposes only. The official leaflet in the language of the country of delivery is supplied with the order.

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Treclin

128.03 KB Mar 2026 Gel 1 / 0,025 % - 1 tube
Informational leaflet with dosage instructions and safety information.
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