Amlodipine
- Oncedaily 24h pressure control
- Relieves angina and Raynaud’s spasms
- Welltolerated, no heart slowdown
Product Information
Better health begins with the right choices.
Dr. M. Sharoyko
Internal Medicine Physician | MNr. 80134
Dr. Marina Sharoyko is a medical specialist in clinical pharmacology and internal medicine, with additional expertise in cardiology and physiology.
Description
Amlodipine is a long-acting medication used to treat high blood pressure. It belongs to a group of drugs called calcium channel blockers. These work by relaxing the blood vessels, allowing blood to flow more easily and reducing the pressure inside the arteries. By lowering blood pressure, Amlodipine helps reduce the risk of stroke, heart attack, and kidney problems. It may be prescribed on its own or in combination with other blood pressure-lowering medications, depending on individual treatment needs.
Amlodipine primarily works by widening the blood vessels themselves. This makes it particularly useful for people whose high blood pressure is related to vascular resistance. It is also commonly used to treat chest pain caused by angina and other circulation-related issues.
Amlodipine is usually taken once a day, and its effects last for a full 24 hours. It comes in tablet form and is generally well tolerated. Because it has a gradual onset, patients may not feel an immediate change, but consistent daily use is essential to achieve long-term benefits. Blood pressure should be monitored regularly during treatment to ensure it remains within the desired range.
Most people experience few side effects with Amlodipine. Some may notice swelling in the ankles or feet, flushing, or a slight headache in the early days of treatment. These symptoms are typically mild and temporary.
General Information
Amlodipine is a longacting calciumchannel blocker tablet that relaxes blood vessels and improves blood flow.
Amlodipine is a calcium channel blocker primarily prescribed for the treatment of high blood pressure (hypertension) and chronic stable angina. It is also used to manage vasospastic angina (Prinzmetal's angina), which is caused by spasm of coronary arteries. Additionally, amlodipine is sometimes used off-label for conditions like Raynaud's phenomenon, where it helps improve blood flow to the extremities.
Amlodipine is a calcium channel blocker that specifically blocks L-type calcium channels in the smooth muscle of the arteries. By preventing the entry of calcium, which is essential for muscle contraction, amlodipine causes the smooth muscle in blood vessel walls to relax and dilate. This leads to a reduction in vascular resistance and a subsequent decrease in blood pressure. In angina, this dilation of arteries improves blood flow to the heart muscle, reducing chest pain.
For most adults, the usual starting dose is 5 mg once daily. If blood pressure or angina is not adequately controlled after 2 to 4 weeks, the dose may be increased to 10 mg daily.
For elderly or frail patients, a lower starting dose of 2.5 mg daily is often recommended to minimize the risk of side effects.
The initial reduction in blood pressure can be observed within hours of taking amlodipine. However, the full steady-state effect on blood pressure typically takes 7 to 8 days of regular use. For angina (chest pain), the frequency of episodes may start to decrease within a week of starting the medication.
If you miss a dose of amlodipine, take it as soon as you remember, but only if it's the same day. If it's been more than 12 hours since the missed dose, skip it and take the next dose at the regular time. Do not take two doses to make up for the missed one.
Safety & Side Effects
- Common: ankle swelling, flushing, headache, dizziness, and mild palpitations. Some users notice tiredness or nausea.
- Rare but serious reactions include severe hypotension, acute chest pain on initiation, or allergic swelling of face or lips (angiooedema).
- Very rarely, liver enzyme rise or gingival overgrowth occurs. An allergic rash or itching demands medical review.
Avoid in severe hypotension (systolic <90 mmHg), shock, or known hypersensitivity to dihydropyridines. Caution in severe aortic stenosis or advanced heartfailure with reduced ejection fraction.
Yes, amlodipine is commonly combined with ACE inhibitors, beta-blockers, or diuretics to enhance blood pressure control.
Grapefruit juice has a minimal effect on amlodipine, so it can generally be consumed without concern.
Strong CYP3A4 inhibitors, such as clarithromycin and itraconazole, can increase amlodipine levels, which may raise the risk of side effects.
Inform your doctor if you are taking HIV protease inhibitors or St. John's wort, as these can affect how amlodipine works or interact with the drug.
Animal data suggest no major harm, but safety is not established; use only if benefit outweighs risk. Small amounts appear in breast milk without reported harm.
Alcohol can enhance vasodilation, augmenting dizzinessrise slowly from sitting.
Usage & Administration
Swallow the tablet whole once daily at the same hour; consistency helps bloodpressure control.
Keep at room temperature below 30 °C, in the original blister until use.
Food has no meaningful effect on the absorption of amlodipine. You can take it with or without meals based on your preference.
Yes, tablets can be crushed and dispersed in water or mixed with nonacidic soft food immediately before intake.
Ordering & Delivery
To get [Product name], fill out a medical form or book a video consult with a doctor via Transtoyou. After approval, your prescription is sent to the pharmacy for fast delivery.
[Product name] requires a valid prescription, which is issued after the doctor reviewed your answered in the medical questionnaire or via a video consultation with the doctor.
After approval by a doctor from Transtoyou, the prescription of [Product name] is forwarded to an affiliated pharmacy and typically shipped within 1–2 working days.
For safety and legal reasons prescription medication (RX) and in this case [Product name] is non-returnable once shipped.
